Repair of Cranial Bone Defects Using rhBMP2 and Submicron Particle of Biphasic Calcium Phosphate Ceramics with Through-Hole

Figure 4

Effects of rhBMP2/d-BCP on bone repair of calvarial defects in mice. d-BCP (10 mg) or rhBMP2 (5 or 10 μg)/d-BCP (10 mg) were implanted into a 5 mm inner diameter cranial defect. Control group was left without any implantation. The mice were harvested at 2 and 8 weeks after implantation, and 2D soft X-ray (a, b) and 3D microcomputed tomography (c, d) analyses were performed. Volume and thickness of regenerative bone were measured using micro-CT apparatus and micro-CT-Analyzer program (e, f). and compared to the indicated group. Representative data are shown. .

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