Transcriptome and Molecular Endocrinology Aspects of Epicardial Adipose Tissue in Cardiovascular Diseases: A Systematic Review and Meta-Analysis of Observational Studies

Table 2

The GO biological processes enriched for the proteins present in the STRING protein network.

GO_id	Term	Genes in test set	Number of genes	value	FDR; value
GO:0009605	Response to external stimulus	TP53; NCF2; SOD2; ADIPOQ; ICAM1; PRKAA2; NCF1; HMOX1; FLT1; MIF; AGT; ADM; RETN; ACSL1; RARRES2; SERPINE1; GSK3B; AGTR1; NOS3; CYBB; EDN1; IL-10; LRP1; MRC1; TNF-α; PLA2G2A	26	1.12 × 10^−18	1.51 × 10^−14
GO:0007568	Aging	IL-10; AGT; ADM; LRP1; IL-6; ICAM1; RETN; SIRT1; NCF2; SERPINE1; MIF; CCL2; EDN1;	13	2.75 × 10^−16	1.85 × 10^−12
GO:0014823	Response to activity	IL-10; NCF2; AGT; SOD2; ADIPOQ; TNF-α; EDN1; CCL2	8	5.53 × 10^−14	2.48 × 10^−10
GO:0071216	Cellular response to biotic stimulus	IL-10; SERPINE1; TNF-α; GSK3B; IL-6; ICAM1; CCL2; TP53; MRC1; NOS3	10	1.09 × 10^−13	3.68 × 10^−10
GO:0032496	Response to lipopolysaccharide	IL-10; ADM; ICAM1; MRC1; NOS3; NCF2; SERPINE1; TNF-α; CCL2; SOD2; EDN1	11	1.43 × 10^−12	3.85 × 10^−9
GO:0002237	Response to molecule of bacterial origin	IL-10; ADM; ICAM1; MRC1; NOS3; SERPINE1; NCF2; TNF-α; CCL2; SOD2; EDN1	11	2.33 × 10^−12	5.23 × 10^−9
GO:0070482	Response to oxygen levels	ADM; ICAM1; TP53; NCF2; SIRT1; TNF-α; CCL2; SOD2; SLC2A4; ADIPOQ; EDN1	11	3.42 × 10^−12	6.57 × 10^−09
GO:0023057	Negative regulation of signaling	TP53; NOS3; CIDEA; SOD2; ADIPOQ; EDN1; IL-10; LRP1; ICAM1; PRKAA2; TNF-α; HMOX1; MIF; AGT; ADM; IL-6; SERPINE1	17	4.07 × 10^−12	6.79 × 10^−9
GO:0010648	Negative regulation of cell communication	TP53; NOS3; CIDEA; SOD2; ADIPOQ; EDN1; IL-10; LRP1; ICAM1; PRKAA2; TNF-α; HMOX1; MIF; AGT; ADM; IL-6; SERPINE1	17	4.54 × 10^−12	6.79 × 10^−9
GO:0045428	Regulation of nitric oxide biosynthetic process	IL-10; AGT; SOD2; TNF-α; EDN1; IL-6; ICAM1	7	6.29 × 10^−12	8.45 × 10^−9