Patient Acceptable Symptom State in Self-Report Questionnaires and Composite Clinical Disease Index for Assessing Rheumatoid Arthritis Activity: Identification of Cut-Off Points for Routine Care

Table 1

Demographic and disease severity characteristics of patients with RA according to PASS status.

	PASS negative				PASS positive				All patients
	Answer, = 248				Answer, = 55				= 303
	Mean	SD	Median	IQR	Mean	SD	Median	IQR	Mean	SD	Median	IQR
Women sex, number (%)	201 (82.0)				44 (80.0)				245 (80.8)
Age, mean ± SD years	54.1 ± 10.1				59.7 ± 9.6				56.9 ± 9.9
Disease duration, mean ± SD years	4.9 ± 3.7				6.9 ± 4.1				5.9 ± 3.9
PRO-CLARA (0–10 scale)	4.026	1.2748	3.920	3.020–4.715	1.969	0.8057	1.960	1.422–2.510	3.652	1.4407	3.540	2.755–4.578
(i) ROAD (0–10 scale)	2.679	2.0410	2.500	0.630–3.960	0.861	0.5924	0.630	0.420–1.040	2.349	1.9906	2.080	0.630–3.130
(ii) Self-administered TJC (0–10)	1.609	1.5868	1.040	0.525–2.080	0.721	0.4474	0.630	0.420–0.830	1.448	1.4875	0.830	0.420–1.880
(iii) Patient’s assessment of disease activity (0–10 NRS)	7.790	1.7554	8.000	7.000–9.000	4.618	2.4381	5.000	3.000–6.000	7.215	2.2545	8.000	6.000–9.000
RAID (0–10 scale)	4.554	2.1946	4.935	2.405–6.070	1.709	0.9731	1.760	1.145–2.098	4.038	2.3055	3.760	1.897–5.790
(i) Pain (0–10 NRS)	3.573	2.5600	3.000	1.500–5.000	1.745	1.5542	1.000	1.000–2.000	3.241	2.5079	3.000	1.000–5.000
(ii) Functional disability (0–10 NRS)	4.690	2.4978	5.000	2.000–7.000	2.018	1.2396	2.000	1.000–2.000	4.205	2.5380	4.000	2.000–6.000
(iii) Fatigue (0–10 NRS)	5.153	3.0977	5.000	2.000–8.000	2.382	1.8806	2.000	1.000–3.000	4.650	3.1025	4.000	2.000–8.000
(iv) Sleep (0–10 NRS)	2.431	2.7076	2.000	0.000–4.000	0.582	1.1497	0.000	0.000–1.000	2.096	2.5966	1.000	0.000–3.000
(v) Physical wellbeing (0–10 NRS)	2.919	2.5343	2.000	1.000–4.000	1.436	1.2136	1.000	1.000–2.000	2.650	2.4175	2.000	1.000–4.000
(vi) Emotional wellbeing (0–10 NRS)	4.577	3.3407	5.000	1.000–8.000	1.327	1.8059	1.000	0.000–2.000	3.987	3.3593	3.000	1.000–8.000
(vii) Coping (0–10 NRS)	7.698	1.9198	8.000	6.000–9.000	3.891	2.8328	4.000	1.000–6.000	7.007	2.5708	8.000	6.000–9.000
CDAI (0–76)	20.538	5.5005	19.830	17.310–24.460	8.757	6.1678	8.210	2.79–13.83	18.407	7.2233	18.710	15.080–23.420

IQR = interquartile range (25th–75th percentile); PRO-CLARA = patient-reported outcome-CLinical ARthritis Activity; ROAD = Recent-Onset Arthritis Disability; TJC = tender joint count; RAID = Rheumatoid Arthritis Impact of Disease; CDAI = Clinical Disease Activity Index.