Minocycline Protection of Neomycin Induced Hearing Loss in Gerbils

Figure 1

Auditory-evoked brainstem response (ABR) threshold shifts (left ears received transtympanic neomycin) for 0 mg/kg, 1.2 mg/kg, and 1.5 mg/kg I.P. minocycline treated gerbils. Plots represent subtraction of baseline (week 0) thresholds from week 4 thresholds over approximate frequency range of 2–20 kHz. In the 6–19 KHz range the threshold shifts of 1.2 mg/kg and 1.5 mg/kg minocycline treated animals were not significantly different from each other but were significantly less than threshold shifts of the 0 mg/kg animals (see Table 1 and methods for Fisher’s exact statistical test of data). Error bars are standard deviation from mean threshold shifts.