Minocycline Protection of Neomycin Induced Hearing Loss in Gerbils

Figure 3

Organ of Corti within the left ears of 0 mg/kg minocycline treated animals (a, b, and c); the upper middle and middle turns (a) and (b), respectively, had identifiable outer hair cells, while upper basal turns were often devoid of hair cells (c). In the corresponding right ear internal animal controls, the upper middle (d) and middle turns (f), had hair cells as the left ears did, while the upper basal turn (f) had outer hair cells, unlike the left ear. This shows that the neomycin treatment of the left ear caused hair cell loss. Panel (d) is annotated to show inner hair cell (IHC) with arrows indicating outer hair cell rows 1, 2, and 3 which lie immediately above the dark purple nuclei of Deiters cells 1, 2, and 3. Solid arrows indicate outer hair cells. Bar = 50 μm.

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