Utility of C-Reactive Protein Levels for Early Prediction of Dengue Severity in Adults
Table 1
Patient characteristics.
Variable
Demographics and comorbid conditions1
Mean age (±SD), years
52.6 (16.0)
Male, (%)
91 (47.6)
Type 2 diabetes mellitus, (%)
41 (21.5)
Essential hypertension, (%)
60 (31.4)
Chronic kidney disease, (%)
11 (5.8)
Previous stroke, (%)
5 (2.1)
Dengue virus serotype, n/N (%)
Serotype 1
5/90 (5.6)
Serotype 2
63/90 (70)
Serotype 3
22/90 (24.4)
Serotype 4
0
Dengue severity, (%)
1997 WHO classification
DF
122 (63.9)
Nonshock DHF
63 (32.9)
DSS
6 (3.1)
2009 WHO classification
Nonsevere dengue
176 (92.1)
Severe dengue
15 (7.9)
Clinical features at hospital presentation2
Mean day from onset illness to presentation (±SD)
3.4 (1.7)
Fever, (%)
182 (95.3)
Abdominal pain, (%)
47 (24.6)
Orbital pain, (%)
26 (13.6)
Bone pain, (%)
69 (36.1)
Myalgia, (%)
104 (54.5)
Headache, (%)
67 (35.1)
Rashes, (%)
38 (20)
Vomiting/nausea, (%)
47 (24.6)
Diarrhea, (%)
43 (22.5)
Petechial, (%)
40 (20.9)
Cough, (%)
47 (24.6)
Dizziness, (%)
43 (22.5)
Gastrointestinal bleeding, (%)
15 (7.9)
Gum bleeding, (%)
23 (12)
Laboratory features and outcome
Leukopenia (WBC < 3.0 × 109 cells/L), (%)
57 (29.8)
Mean hematocrit (±SD) (%), ()
41 ± 4.5 ()
Mean platelet count (±SD) (×109 cells/L), ()
62.6 ± 45.1 ()
Mean CRP (±SD) mg/L
19.3 (27.6)
Fatality, (%)
3 (1.6)
CRP = C-reactive protein; DF = dengue fever; DHF = dengue hemorrhagic fever; DSS = dengue shock syndrome; WBC = white blood cell count; WHO = World Health Organization. 1An individual patient might have more than one underlying disease/condition. 2An individual patient might have more than one symptom and/or sign.
