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BioMed Research International
Volume 2015 (2015), Article ID 936307, 7 pages
http://dx.doi.org/10.1155/2015/936307
Clinical Study

Zoledronic Acid May Reduce Intraoperative Bleeding in Spinal Tumors: A Prospective Cohort Study

1Department of Pharmacy, Chengdu Military General Hospital, Chengdu 610083, China
2Department of Orthopedics, Chengdu Military General Hospital, Chengdu 610083, China
3Department of Orthopedics, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China
4Department of Science and Training, Chengdu Military General Hospital, Chengdu 610083, China
5Department of Training, Second Military Medical University, Shanghai 200433, China

Received 11 August 2014; Accepted 11 October 2014

Academic Editor: Kuo-Sheng Hung

Copyright © 2015 Juan Wu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Between June 2010 and June 2011, 176 patients were divided into 2 groups: a group with spinal metastasis of solid tumors () and a group with multiple myeloma (). Both groups were further divided into 2 subgroups: a group receiving zoledronic acid before surgery and a control group. The zoledronic acid subgroup of the solid tumors group was group A (), the control subgroup of the solid tumors group was group B (), the zoledronic acid subgroup of the multiple myeloma group was group C (), and the control subgroup of the multiple myeloma group was group D (). The average intraoperative blood loss during spinal surgery was as follows:  mL in group A and  mL in group B () and  mL in group C and  mL in group D (). Patients receiving zoledronic acid before surgery had significantly less intraoperative bleeding than those who did not receive it. Preoperative use of zoledronic acid can effectively reduce intraoperative bleeding during surgery for the treatment of spinal tumors.