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BioMed Research International
Volume 2015, Article ID 938747, 6 pages
http://dx.doi.org/10.1155/2015/938747
Research Article

Evaluation of Antileishmanial Activity of Albaha Medicinal Plants against Leishmania amazonensis

1Department of Biology, Faculty of Sciences, Al Baha University, Saudi Arabia
2Pharmacognosy Department, Faculty of Clinical Pharmacy, Al Baha University, Saudi Arabia
3Departamento de Parasitología, Instituto de Medicina Tropical Pedro Kourí, La Habana, Cuba
4Pharmacognosy Department, Faculty of Pharmacy, Aden University, P.O. Box 5411, Ma’alla, Aden, Yemen

Received 1 July 2015; Accepted 4 August 2015

Academic Editor: Yu-Ping Tang

Copyright © 2015 Saeed S. Al-Sokari et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Sixteen methanolic extracts obtained from thirteen plant species, selected either from ethnobotanical or chemotaxonomical data, were screened for their antileishmanial activity against Leishmania amazonensis. The cytotoxic activity against normal peritoneal macrophages from normal BALB/c mice was also determined. Eight extracts had IC50 values ranging from <12.5 to 37.8 µg/mL against promastigotes. Achillea biebersteinii flower, Euphorbia helioscopia, and Solanum incanum leaf extracts showed antileishmanial activities with IC50 between <12.5–26.9 µg/mL and acceptable selectivity indices of 8–5. The other leishmanicidal plant extracts, with IC50 ranging from 18.0 to 29.5 µg/mL, exhibited low selectivity indices.