Research Article
Evaluation of Antileishmanial Activity of Albaha Medicinal Plants against Leishmania amazonensis
Table 2
Activity and cytotoxicity of plant extracts against L. amazonensis and peritoneal macrophage from BALB/c mice, respectively.
| | Species (part testeda) | (μg/mL)
Promastigotes | (μg/mL)
Macrophage | SIe | (μg/mL)
Amastigotes |
| | A. biebersteinii (Fl) | 26.9 ± 2.9 | 131.3 ± 6.1 | 5 | 13.6 ± 0.6 | | A. biebersteinii (L) | >200 | — | — | — | | C. procera (L) | >200 | — | — | — | | C. murale (F) | >200 | — | — | — | | Myrrha resin (Re) | 17.5 ± 0.01 | 49.8 ± 2.0 | 3 | — | | D. viscosa (L) | >200 | — | — | — | | E. helioscopia (AP) | <12.5 | 82.5 ± 4.4 | 7 | 31.1 ± 3.9 | | L. dentata (AP) | >200 | — | — | — | | P. crispa (AP) | 23.5 ± 2.5 | 79.0 ± 7.3 | 3 | — | | P. granatum (Fl) | >200 | — | — | — | | R. chalepensis (L) | >200 | — | — | — | | S. incanum (F) | 37.8 ± 2.7 | 174.6 ± 6.9 | 5 | 24.4 ± 3.0 | | S. incanum (L) | 18.0 ± 2.8 | 149.2 ± 3.8 | 8 | 31.0 ± 3.8 | | V. encelioides (L) | >200 | — | — | — | | W. somnifera (F) | 29.5 ± 1.0 | 84.9 ± 4.7 | 3 | — | | W. somnifera (L) | 20.3 ± 6.8 | <12.5 | 0 | — |
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AP, aerial parts; F: fruits; L: leaves; Re: resins; Fl: flowers.
bIC50: Concentration of extract causing 50% growth inhibition.
cSD: Standard deviation.
dCC50: Concentration of extract causing 50% of mortality of peritoneal macrophage from BALB/c.
eSI: Selectivity index. —: Not done.
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