Review Article

Mechanisms and Clinical Applications of Genome Instability in Multiple Myeloma

Table 1

Recurrent chromosomal aberrations observed in MM and their prognostic relevance.

AberrationIncidenceOutcome

Trisomies of chromosomes 3, 5, 7, 11, 15, 19, and 21 60%Favorable
t(4;14)15%Poor
t(11;14)20%Favorable
t(14;16)6-7%Poor
del(17p) 8–10%Poor