Review Article
Mechanisms and Clinical Applications of Genome Instability in Multiple Myeloma
Table 2
Summary of molecules involved in DNA damage and frequencies of their mutations.
| Genes | Walker et al. () | Lohr et al. () | Bolli et al. () | Chapman et al. () | Cifola et al. () |
| ATM | 18 (3%) | 8 (3.9%) | 2 (3%) | 1 (2.6%) | 4 (34%) | ATR | 6 (1.3%) | 2 (1%) | 1 (1.5%) | 0 | 3 (25%) | XRCC4 | 0 | 0 | 1 (1.5%) | 0 | 0 | RNF168 | 0 | 2 (1%) | 2 (3%) | 1 (2.6%) | 0 | BRCA1/2 | 0 | 2 (1%) | 1 (1.5%) | 1 (2.6%) | 2 (34%) |
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Plasma cell leukemias.
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