Mechanisms and Clinical Applications of Genome Instability in Multiple Myeloma

Table 2

Summary of molecules involved in DNA damage and frequencies of their mutations.

Genes	Walker et al. ()	Lohr et al. ()	Bolli et al. ()	Chapman et al. ()	Cifola et al. ()
ATM	18 (3%)	8 (3.9%)	2 (3%)	1 (2.6%)	4 (34%)
ATR	6 (1.3%)	2 (1%)	1 (1.5%)	0	3 (25%)
XRCC4	0	0	1 (1.5%)	0	0
RNF168	0	2 (1%)	2 (3%)	1 (2.6%)	0
BRCA1/2	0	2 (1%)	1 (1.5%)	1 (2.6%)	2 (34%)

Plasma cell leukemias.