Management of Chemotherapy Induced Nausea and Vomiting in Patients on Multiday Cisplatin Based Combination Chemotherapy

Table 2

Antiemetic prophylaxis regimen for multiday cisplatin chemotherapy for germ cell tumors, Indiana University protocol.

Day 1	Day 2	Day 3	Day 4	Day 5	Days 6–8
Dexamethasone 20 mg IV	Dexamethasone 20 mg IV	Palonosetron 0.25 mg IV		Palonosetron 0.25 mg IV	Dexamethasone 4 mg BID PO
Palonosetron 0.25 mg IV		Fosaprepitant 150 mg IV		Fosaprepitant 150 mg IV

Alternatively, ondansetron 16 mg orally daily can be utilized from days 1–5 if palonosetron is not available.