BioMed Research International / 2015 / Article / Tab 1

Research Article

Risk Factors and Scoring System for Predicting Bacterial Resistance to Cefepime as Used Empirically in Haematology Wards

Table 1

Baseline characteristics and clinical features at onset of the first episode of bacteraemia in the haematology ward.

CharacteristicAll patientsCefepime resistanceNo cefepime resistance

Patient characteristics
 Age, mean (SD), yr53 (16)51 (16)54 (16)0.32
 Female, (%)45 (43)23 (46)22 (42)0.65
 Primary diagnosis, (%)
  Acute myeloid leukaemia and myelodysplastic syndrome71 (68)30 (60)41 (77)
  Acute lymphoblastic leukaemiab13 (13)11 (22)2 (4)0.005
  Lymphoma or myeloma13 (13)5 (10)8 (15)
  Nonmalignant haematological disease6 (6)4 (8)2 (4)
 Phase of therapy, (%)
  No chemotherapy in the previous 2 months11 (11)5 (10)6 (11)
  Inductionc26 (25)15 (30)11 (21)0.28
  Relapse20 (20)9 (18)11 (21)
  Consolidation21 (20)8 (16)13 (24)
  Allogeneic Stem Cell Transplant25 (24)13 (26)12 (23)
 Graft-versus-host disease, (%)d20 (80)11 (85)9 (75)0.64
 Comorbidities, (%)e9 (9)5 (10)4 (8)0.66
Risk factors in the month preceding bacteraemia
 Transfer from abroad, (%)6 (6)4 (8)2 (4)0.43
 Intensive care unit, (%)3 (3)3 (6)00.11
 Surgery, (%)3 (3)2 (4)1 (2)0.61
 Antibiotic therapy with betalactams25 (24)18 (36)7 (13)0.007
Risk factors at the onset of bacteraemia
 Neutrophil count, (%)
  Neutrophils ≥500/mm327 (26)13 (26)14 (26)0.56
  Neutrophils 100–500/mm314 (14)5 (10)9 (17)
  Neutrophils <100/mm362 (60)32 (64)30 (57)
 Corticosteroid therapy, (%)15 (15)9 (18)6 (11)0.34
 Another immunosuppressive therapy, (%)23 (22)13 (26)10 (19)0.39
 Severe mucositis, (%)8 (8)6 (12)2 (4)0.15
 Gut decontamination, (%)76 (74)39 (78)37 (70)0.35
 Antibiotic therapy with β-lactams, (%)21 (20)17 (34)4 (19)0.001
 Time elapsed since hospital admission, mean (SD), days15 (13)19 (15)12 (10)0.003
 Central venous catheter, (%)85 (83)42 (84)43 (81)0.70
 Time elapsed since central venous catheter insertion, mean (SD), daysf17 (15)20 (19)14 (11)0.040
 Urinary catheter, (%)1 (1)1 (2)00.49
Clinical features of bacteraemia
 Fever, (%)98 (95)46 (92)52 (98)0.20
 Severe sepsis, (%)17 (17)6 (12)11 (21)0.23
 Shock, (%)4 (4)1 (2)3 (6)0.62
 Unknown origin of bacteraemia, (%)59 (58)31 (62)28 (53)0.35

By chi-square test or Fisher’s exact test for qualitative variables; by Wilcoxon rank-sum test for skewed quantitative variables.
bBy chi-square test comparing acute lymphoblastic leukaemia with other situations.
cBy chi-square test comparing induction with other situations.
dEstimates were computed for 25 patients with ASCT.
e2 chronic obstructive pulmonary disease; 2 chronic heart disease; 2 cirrhosis; 2 diabetes mellitus; 1 diabetes mellitus and cirrhosis.
fEstimates were computed for 85 patients with intravascular catheter.

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