Trichomonas vaginalis Cysteine Proteinases: Iron Response in Gene Expression and Proteolytic Activity

Table 1

Cysteine proteinases in virulence properties of Trichomonas vaginalis.

Proteinase	Virulence properties	Regulation by iron	Type of regulation	Ref.
CP (30 kDa)	Cytoskeleton disruption	ND	ND	[61]
TvCP4	Hemolysis	+	Posttranscriptional level	[36, 58]
TvCP12	Cytotoxicity	−	Posttranscriptional level	[7, 54, 57]
TvCP30	Cytoadherence; Protein degradation	−	ND	[7, 52]
TvCP39	Cytotoxicity; Igs Degradation	−	Posttranscriptional level; Posttranslational level	[7, 52, 57]
TvCP62	Cytoadherence	+	ND	[52, 55]
TvCP65	Cytotoxicity	−	Transcriptional level; Posttranscriptional level; Posttranslational level	[7, 52, 56]
CP2, CP3, CP4, and CPT	Induction of host cell apoptosis	−	ND	[65, 66]
CP1	ND	ND	Transcriptional level	[27, 35, 71]
TvLEGU-1	Cytoadherence	+	Transcriptional level; Posttranslational level	[7, 43, 52, 54]

ND: not determined; upregulated (+); downregulated (−).