Mycobacterium-Host Cell Relationships in Granulomatous Lesions in a Mouse Model of Latent Tuberculous Infection

Figure 2

(a–d) Granulomas (Gran) obtained from the lungs (L/), spleens (S/), and bone marrow (BM/) of mice after 20 days (/20 d), one month (/1 m), and two months (/2 m) following infection with BCG in vivo and after ex vivo culture for several days, in which macrophages (Mph) or dendritic cells (DC) with acid-fast BCG-mycobacteria (BCG) in them were counted. ((a) and (b)) The figures represent the total number of granulomas with infected Mph and DC and the number of granulomas with Mph and DC with colonies of replicating BCG-mycobacteria expressed as a percentage of the total number of granulomas inspected. ((c) and (d)) The number of Mph (and DC) with any BCG (single or as colonies) and with colonies of replicating BCG, both expressed as a percentage of the total number of granuloma Mph (and DC). Data are expressed as the means ± SEM. () Leukocyte infiltrates from mouse 6 S/2 m.

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