Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2015, Article ID 948267, 8 pages
http://dx.doi.org/10.1155/2015/948267
Research Article

The Impact of Sequence of Chemotherapy and EGFR-TKI Treatment on Different EGFR Mutation Lung Adenocarcinoma

1Department of Thoracic Medicine, Saint Paul’s Hospital, Taoyuan 330, Taiwan
2Department of Thoracic Medicine, Chang Gung Memorial Hospital at Linkou, Chang Gung University, College of Medicine, Taipei 10507, Taiwan
3Department of Internal Medicine, Saint Paul’s Hospital, Taoyuan 330, Taiwan
4Department of Internal Medicine, Chang Gung Memorial Hospital at Linkou, Chang Gung University, College of Medicine, Taipei 10507, Taiwan

Received 16 April 2015; Accepted 22 July 2015

Academic Editor: Sherven Sharma

Copyright © 2015 Fu-Tsai Chung et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. S. Sun, J. H. Schiller, and A. F. Gazdar, “Lung cancer in never smokers—a different disease,” Nature Reviews Cancer, vol. 7, no. 10, pp. 778–790, 2007. View at Publisher · View at Google Scholar · View at Scopus
  2. R. S. Herbst, J. V. Heymach, and S. M. Lippman, “Lung cancer,” The New England Journal of Medicine, vol. 359, no. 13, pp. 1367–1380, 2008. View at Publisher · View at Google Scholar · View at Scopus
  3. L. V. Sequist, D. W. Bell, T. J. Lynch, and D. A. Haber, “Molecular predictors of response to epidermal growth factor receptor antagonists in non-small-cell lung cancer,” Journal of Clinical Oncology, vol. 25, no. 5, pp. 587–595, 2007. View at Publisher · View at Google Scholar · View at Scopus
  4. F. Ciardiello and G. Tortora, “Drug therapy: EGFR antagonists in cancer treatment,” The New England Journal of Medicine, vol. 358, no. 11, pp. 1160–1174, 2008. View at Publisher · View at Google Scholar · View at Scopus
  5. T. J. Lynch, D. W. Bell, R. Sordella et al., “Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib,” The New England Journal of Medicine, vol. 350, no. 21, pp. 2129–2139, 2004. View at Publisher · View at Google Scholar · View at Scopus
  6. R. Rosell, T. Moran, C. Queralt et al., “Screening for epidermal growth factor receptor mutations in lung cancer,” The New England Journal of Medicine, vol. 361, no. 10, pp. 958–967, 2009. View at Publisher · View at Google Scholar · View at Scopus
  7. W. Pao, V. Miller, M. Zakowski et al., “EGF receptor gene mutations are common in lung cancers from ‘never smokers’ and are associated with sensitivity of tumors to gefitinib and erlotinib,” Proceedings of the National Academy of Sciences of the United States of America, vol. 101, no. 36, pp. 13306–13311, 2004. View at Publisher · View at Google Scholar · View at Scopus
  8. T. S. Mok, Y.-L. Wu, S. Thongprasert et al., “Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma,” The New England Journal of Medicine, vol. 361, no. 10, pp. 947–957, 2009. View at Publisher · View at Google Scholar · View at Scopus
  9. T. Mitsudomi, S. Morita, Y. Yatabe et al., “Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): an open label, randomised phase 3 trial,” The Lancet Oncology, vol. 11, no. 2, pp. 121–128, 2010. View at Publisher · View at Google Scholar · View at Scopus
  10. E. A. Eisenhauer, P. Therasse, J. Bogaerts et al., “New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1),” European Journal of Cancer, vol. 45, no. 2, pp. 228–247, 2009. View at Publisher · View at Google Scholar · View at Scopus
  11. F.-T. Chung, K.-Y. Lee, C.-W. Wang et al., “Tumor-associated macrophages correlate with response to epidermal growth factor receptor-tyrosine kinase inhibitors in advanced non-small cell lung cancer,” International Journal of Cancer, vol. 131, no. 3, pp. E227–E235, 2012. View at Publisher · View at Google Scholar · View at Scopus
  12. C. Gridelli, F. Ciardiello, C. Gallo et al., “First-line erlotinib followed by second-line cisplatin-gemcitabine chemotherapy in advanced non-small-cell lung cancer: the TORCH randomized trial,” Journal of Clinical Oncology, vol. 30, no. 24, pp. 3002–3011, 2012. View at Publisher · View at Google Scholar
  13. L. Zhang, S. Ma, X. Song et al., “Gefitinib versus placebo as maintenance therapy in patients with locally advanced or metastatic non-small-cell lung cancer (INFORM; C-TONG 0804): a multicentre, double-blind randomised phase 3 trial,” The Lancet Oncology, vol. 13, no. 5, pp. 466–475, 2012. View at Publisher · View at Google Scholar · View at Scopus
  14. K. Takeda, T. Hida, T. Sato et al., “Randomized phase III trial of platinum-doublet chemotherapy followed by gefitinib compared with continued platinum-doublet chemotherapy in Japanese patients with advanced non-small-cell lung cancer: results of a West Japan Thoracic Oncology Group Trial (WJTOG0203),” Journal of Clinical Oncology, vol. 28, no. 5, pp. 753–760, 2010. View at Publisher · View at Google Scholar · View at Scopus
  15. W. Brugger, N. Triller, M. Blasinska-Morawiec et al., “Prospective molecular marker analyses of EGFR and KRAS from a randomized, placebo-controlled study of erlotinib maintenance therapy in advanced non-small-cell lung cancer,” Journal of Clinical Oncology, vol. 29, no. 31, pp. 4113–4120, 2011. View at Publisher · View at Google Scholar · View at Scopus
  16. R. J. Cersosimo, “Gefitinib: an adverse effects profile,” Expert Opinion on Drug Safety, vol. 5, no. 3, pp. 469–479, 2006. View at Publisher · View at Google Scholar · View at Scopus
  17. M. Maemondo, Y. Minegishi, A. Inoue et al., “First-line gefitinib in patients aged 75 or older with advanced non-small cell lung cancer harboring epidermal growth factor receptor mutations. NEJ 003 study,” Journal of Thoracic Oncology, vol. 7, no. 9, pp. 1417–1422, 2012. View at Publisher · View at Google Scholar · View at Scopus
  18. S. Kobayashi, T. J. Boggon, T. Dayaram et al., “EGFR mutation and resistance of non-small-cell lung cancer to gefitinib,” The New England Journal of Medicine, vol. 352, no. 8, pp. 786–792, 2005. View at Publisher · View at Google Scholar · View at Scopus
  19. J. A. Engelman, K. Zejnullahu, T. Mitsudomi et al., “MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling,” Science, vol. 316, no. 5827, pp. 1039–1043, 2007. View at Publisher · View at Google Scholar · View at Scopus
  20. T. Ciuleanu, L. Stelmakh, S. Cicenas et al., “Efficacy and safety of erlotinib versus chemotherapy in second-line treatment of patients with advanced, non-small-cell lung cancer with poor prognosis (TITAN): a randomised multicentre, open-label, phase 3 study,” The Lancet Oncology, vol. 13, no. 3, pp. 300–308, 2012. View at Publisher · View at Google Scholar · View at Scopus
  21. F. Cappuzzo, T. Ciuleanu, L. Stelmakh et al., “Erlotinib as maintenance treatment in advanced non-small-cell lung cancer: a multicentre, randomised, placebo-controlled phase 3 study,” The Lancet Oncology, vol. 11, no. 6, pp. 521–529, 2010. View at Publisher · View at Google Scholar · View at Scopus
  22. M. Maemondo, A. Inoue, K. Kobayashi et al., “Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR,” The New England Journal of Medicine, vol. 362, no. 25, pp. 2380–2388, 2010. View at Publisher · View at Google Scholar · View at Scopus
  23. C. G. Azzoli, S. Temin, and G. Giaccone, “2011 focused update of 2009 American society of clinical oncology clinical practice guideline update on chemotherapy for stage IV non-small-cell lung cancer,” Journal of Oncology Practice, vol. 8, no. 1, pp. 63–66, 2012. View at Publisher · View at Google Scholar · View at Scopus
  24. J. C.-H. Yang, Y.-L. Wu, M. Schuler et al., “Afatinib versus cisplatin-based Chemotherapy for EGFR mutation-positive lung adenocarcinoma (LUX-Lung 3 and LUX-Lung 6): analysis of overall survival data from two randomised, phase 3 trials,” The Lancet Oncology, vol. 16, no. 2, pp. 141–151, 2015. View at Publisher · View at Google Scholar · View at Scopus