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BioMed Research International
Volume 2015, Article ID 948610, 10 pages
Review Article

Focus on Diffusion MR Investigations of Musculoskeletal Tissue to Improve Osteoporosis Diagnosis: A Brief Practical Review

1CNR-IPCF UOS Roma Sapienza, Physics Department, “Sapienza” University of Rome, Italy
2Department of Orthopaedics and Traumatology, PTV Foundation, “Tor Vergata” University of Rome, Italy
3Department of Diagnostic and Interventional Radiology, Molecular Imaging and Radiotherapy, PTV Foundation, “Tor Vergata” University of Rome, Italy

Received 28 October 2014; Accepted 18 February 2015

Academic Editor: Jimin Ren

Copyright © 2015 Silvia Capuani et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Nowadays, a huge number of papers have documented the ability of diffusion magnetic resonance imaging (D-MRI) to highlight normal and pathological conditions in a variety of cerebral, abdominal, and cardiovascular applications. To date, however, the role of D-MRI to investigate musculoskeletal tissue, specifically the cancellous bone, has not been extensively explored. In order to determine potentially useful applications of diffusion techniques in musculoskeletal investigation, D-MRI applications to detect osteoporosis disease were reviewed and further explained.