Transcriptional Changes Associated with Long-Term Left Ventricle Volume Overload in Rats: Impact on Enzymes Related to Myocardial Energy Metabolism

Figure 3

Impact of an 8-week fenofibrate treatment on LV remodeling, function, and energetics as evaluated by μPET. (a) Left ventricular volumes and ejection fraction as evaluated by [¹⁸F]-FTHA μPET. End-diastolic (EDV) and end-systolic (ESV) volumes were measured as described in Section 2. The ejection fraction is the ratio of SV (EDV-ESV) on EDV. Results are reported as the mean of data obtained from four animals/group ± SEM.: between sham and AR groups. and untreated AR group. The box represents the mean ± SEM of sham animals. (b) A three-dimensional reconstruction of the LV of a sham (top) and an AR rat (bottom) 6 months after surgery. (d) The same analysis was then reproduced for each segment of the LV wall as schematized in the bottom right of this panel. between sham and AR groups. Sept: septal wall, Ant: anterior wall, Lat: lateral wall, and Inf: inferior wall. between sham and AR groups. and untreated AR group.

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