Transcriptional Changes Associated with Long-Term Left Ventricle Volume Overload in Rats: Impact on Enzymes Related to Myocardial Energy Metabolism

Table 3

Echocardiographic data at 9 months.

	Sham ()	AR ()	value
EDD, mm	9.2 ± 0.08	12.2 ± 0.24	<0.0001
ESD, mm	4.5 ± 0.07	7.6 ± 0.09	<0.0001
SW, mm	1.6 ± 0.03	1.8 ± 0.02	<0.0001
PW, mm	1.5 ± 0.42	1.8 ± 0.02	<0.0001
RWT	0.34 ± 0.004	0.29 ± 0.006	<0.0001
FS, %	51 ± 0.3	39 ± 1.3	<0.0001
SV, µL	232 ± 4.8	372 ± 22.2	<0.0001

Measurements obtained under inhaled 1.5% isoflurane anesthesia after 9 months. EDD: end-diastolic diameter, ESD: end-systolic diameter, SW: septal wall, PW: posterior wall, RWT: relative wall thickness, FS: fractional shortening, and SV: stroke volume. Values are expressed as mean ± SEM of the indicated number of animals.