Transcriptional Changes Associated with Long-Term Left Ventricle Volume Overload in Rats: Impact on Enzymes Related to Myocardial Energy Metabolism

Table 4

Upregulated genes in the category “extracellular” from the GO cellular component in 9-month LVs from severe volume overload compared to age-matched sham-operated animals.

Target ID	Definition	Fold change	value
NPPA	Natriuretic peptide precursor type A	6,775	0.00018
TGFB2	Transforming growth factor, beta 2	4,311	0.00005
CTGF	Connective tissue growth factor	4,059	0.00012
CHI3L1	Chitinase 3-like 1	3,775	0.00117
HAMP	Hepcidin antimicrobial peptide	3,397	0.00080
MGP	Matrix Gla protein	3,256	0.00011
LTBP2	Latent transforming growth factor beta binding protein 2	3,067	0.00073
TIMP1	Tissue inhibitor of metallopeptidase 1	2,954	0.00215
CTSS	Cathepsin S	2,912	0.00003
LOXL1	Lysyl oxidase-like 1	2,869	0.00047
PRSS23	Protease, serine, 23	2,788	0.00002
FSTL1	Follistatin-like 1	2,673	0.00033
GPX3	Glutathione peroxidase 3	2,672	0.00011
C1QB	Complement component 1, q subcomponent, beta polypeptide	2,613	0.00007
PTGIS	Prostaglandin I2 (prostacyclin) synthase	2,574	0.00005
SERPING1	Serine (or cysteine) peptidase inhibitor, clade G, member 1	2,520	0.00037
LGALS3	Lectin, galactose binding, soluble 3	2,419	0.00042
PMP22	Peripheral myelin protein 22	2,235	0.00025
IGFBP6	Insulin-like growth factor binding protein 6	2,231	0.00023
FN1	Fibronectin 1	2,230	0.00361
COL1A2	Procollagen, type I, alpha 2	2,212	0.00024
TGFA	Transforming growth factor alpha	2,177	0.00112
C1QA	Complement component 1, q subcomponent, alpha polypeptide	2,142	0.00013
ECM1	Extracellular matrix protein 1	2,098	0.00023
FBN1	Fibrillin 1	2,093	0.00056
MFAP4	Microfibrillar-associated protein 4	2,076	0.00009
FXYD6	FXYD domain-containing ion transport regulator 6	2,074	0.00115
PLOD2	Procollagen lysine, 2-oxoglutarate 5-dioxygenase 2	2,068	0.00021
WISP2	WNT1 inducible signaling pathway protein 2	2,060	0.00136
CTSK	Cathepsin K	2,051	0.00018
C1S	Complement component 1, s subcomponent	2,028	0.00210
APOE	Apolipoprotein E	2,027	0.00059
MXRA8	Matrix-remodelling associated 8	1,964	0.00027
NPPB	Natriuretic peptide precursor type B	1,924	0.00016
LUM	Lumican	1,902	0.00021
PCDH21	MT-protocadherin	1,861	0.00102
CD14	CD14 antigen	1,845	0.00003
TF	Transferrin	1,844	0.00089
C2	Complement component 2	1,807	0.00119
PPT1	Palmitoyl-protein thioesterase 1	1,753	0.00007
GDF15	Growth differentiation factor 15	1,705	0.00016
CX3CL1	Chemokine (C-X3-C motif) ligand 1	1,679	0.00108
AOC3	Amine oxidase, copper containing 3	1,666	0.00093
CCL7	Chemokine (C-C motif) ligand 7	1,665	0.00284
NBL1	Neuroblastoma, suppression of tumorigenicity 1	1,661	0.00048
GRN	Granulin	1,634	0.00010
SERPINF1	Serine (or cysteine) peptidase inhibitor, clade F, member 1	1,634	0.00038
CTSB	Cathepsin B	1,610	0.00005
FXYD5	FXYD domain-containing ion transport regulator 5	1,604	0.00167
TRH	Thyrotropin releasing hormone	1,588	0.00306
PRELP	Proline arginine-rich end leucine-rich repeat protein	1,580	0.00127
STC1	Stanniocalcin 1	1,550	0.00049
COL5A1	Procollagen, type V, alpha 1	1,536	0.00065
CD48	CD48 antigen	1,533	0.00047
PON3	Paraoxonase 3	1,522	0.00508
ITGB1	Integrin beta 1	1,519	0.00002
RARRES2	Retinoic acid receptor responder	1,509	0.00004

FC: fold change versus sham controls.