Table 4: Upregulated genes in the category “extracellular” from the GO cellular component in 9-month LVs from severe volume overload compared to age-matched sham-operated animals.

Target IDDefinitionFold change value

NPPANatriuretic peptide precursor type A 6,775 0.00018
TGFB2Transforming growth factor, beta 2 4,3110.00005
CTGFConnective tissue growth factor 4,0590.00012
CHI3L1Chitinase 3-like 1 3,7750.00117
HAMPHepcidin antimicrobial peptide 3,3970.00080
MGPMatrix Gla protein3,2560.00011
LTBP2Latent transforming growth factor beta binding protein 23,0670.00073
TIMP1Tissue inhibitor of metallopeptidase 1 2,9540.00215
CTSSCathepsin S 2,9120.00003
LOXL1Lysyl oxidase-like 1 2,8690.00047
PRSS23Protease, serine, 232,7880.00002
FSTL1Follistatin-like 12,6730.00033
GPX3Glutathione peroxidase 3 2,6720.00011
C1QBComplement component 1, q subcomponent, beta polypeptide2,6130.00007
PTGISProstaglandin I2 (prostacyclin) synthase 2,5740.00005
SERPING1Serine (or cysteine) peptidase inhibitor, clade G, member 1 2,5200.00037
LGALS3Lectin, galactose binding, soluble 3 2,4190.00042
PMP22Peripheral myelin protein 22 2,2350.00025
IGFBP6Insulin-like growth factor binding protein 6 2,2310.00023
FN1Fibronectin 1 2,2300.00361
COL1A2Procollagen, type I, alpha 2 2,2120.00024
TGFATransforming growth factor alpha 2,1770.00112
C1QAComplement component 1, q subcomponent, alpha polypeptide 2,1420.00013
ECM1Extracellular matrix protein 1 2,0980.00023
FBN1Fibrillin 12,0930.00056
MFAP4Microfibrillar-associated protein 4 2,0760.00009
FXYD6FXYD domain-containing ion transport regulator 6 2,0740.00115
PLOD2Procollagen lysine, 2-oxoglutarate 5-dioxygenase 2 2,0680.00021
WISP2WNT1 inducible signaling pathway protein 2 2,0600.00136
CTSKCathepsin K2,0510.00018
C1SComplement component 1, s subcomponent 2,0280.00210
APOEApolipoprotein E 2,0270.00059
MXRA8Matrix-remodelling associated 8 1,9640.00027
NPPBNatriuretic peptide precursor type B 1,9240.00016
LUMLumican1,9020.00021
PCDH21MT-protocadherin 1,8610.00102
CD14CD14 antigen 1,8450.00003
TFTransferrin 1,8440.00089
C2Complement component 2 1,8070.00119
PPT1Palmitoyl-protein thioesterase 1 1,7530.00007
GDF15Growth differentiation factor 15 1,7050.00016
CX3CL1Chemokine (C-X3-C motif) ligand 1 1,6790.00108
AOC3Amine oxidase, copper containing 31,6660.00093
CCL7Chemokine (C-C motif) ligand 7 1,6650.00284
NBL1Neuroblastoma, suppression of tumorigenicity 1 1,6610.00048
GRNGranulin1,6340.00010
SERPINF1Serine (or cysteine) peptidase inhibitor, clade F, member 1 1,6340.00038
CTSBCathepsin B 1,6100.00005
FXYD5FXYD domain-containing ion transport regulator 5 1,6040.00167
TRHThyrotropin releasing hormone 1,5880.00306
PRELPProline arginine-rich end leucine-rich repeat protein 1,5800.00127
STC1Stanniocalcin 11,5500.00049
COL5A1Procollagen, type V, alpha 1 1,5360.00065
CD48CD48 antigen 1,5330.00047
PON3Paraoxonase 3 1,5220.00508
ITGB1Integrin beta 11,5190.00002
RARRES2Retinoic acid receptor responder 1,5090.00004

FC: fold change versus sham controls.