Transcriptional Changes Associated with Long-Term Left Ventricle Volume Overload in Rats: Impact on Enzymes Related to Myocardial Energy Metabolism

Table 5

Downregulated genes in the category “mitochondrion” from the GO cellular component in 9-month LVs from severe volume overload compared to age-matched sham-operated animals.

Target ID	Definition	Fold change	value
CYP11A1	Cytochrome P450, family 11, subfamily a, polypeptide 1	0,482	0.00057
ECH1	Enoyl-Coenzyme A hydratase 1, peroxisomal	0,497	0.00039
HADHA	Hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit	0,517	0.00030
DECR1	2,4-Dienoyl CoA reductase 1, mitochondrial	0,519	0.00343
ACAA2	Acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-Coenzyme A thiolase)	0,523	0.00536
LDHD	Lactate dehydrogenase D	0,540	0.00088
DCI	Dodecenoyl-coenzyme A delta isomerase	0,541	0.00037
ACAT1	Acetyl-coenzyme A acetyltransferase 1	0,541	0.00023
PKM2	Pyruvate kinase, muscle	0,547	0.00020
MLYCD	Malonyl-CoA decarboxylase	0,554	0.00111
BCAT2	Branched chain aminotransferase 2, mitochondrial	0,557	0.00184
GSTK1	Glutathione S-transferase kappa 1	0,572	0.00035
FAHD1	Fumarylacetoacetate hydrolase domain containing 1	0,581	0.00008
DHRS4	Dehydrogenase/reductase (SDR family) member 4	0,585	0.00035
HSD17B8	Hydroxysteroid (17-beta) dehydrogenase 8	0,585	0.00018
ACSL1	Acyl-CoA synthetase long-chain family member 1	0,589	0.00023
BCKDHA	Branched chain ketoacid dehydrogenase E1, alpha polypeptide	0,593	0.00109
ACADVL	Acyl-Coenzyme A dehydrogenase, very long chain	0,597	0.00089
SLC25A20	Solute carrier family 25 (mitochondrial carnitine/acylcarnitine translocase), member 20	0,598	0.00021
ACO2	Aconitase 2, mitochondrial	0,601	0.00173
LOC56764	DNAJ-like protein	0,607	0.00045
PECR	Peroxisomal trans-2-enoyl-CoA reductase	0,610	0.00033
ECHS1	Enoyl-Coenzyme A hydratase, short chain, 1, mitochondrial	0,616	0.00065
IVD	Isovaleryl coenzyme A dehydrogenase	0,618	0.00098
PDK2	Pyruvate dehydrogenase kinase, isoenzyme 2	0,622	0.00071
MGST1	Microsomal glutathione S-transferase 1	0,623	0.00001
CRAT	Carnitine acetyltransferase	0,630	0.00125
ACADS	Acetyl-Coenzyme A dehydrogenase, short chain	0,635	0.00507
SUCLG1	Succinate-CoA ligase, GDP-forming, alpha subunit	0,637	0.00048
NDUFS7	NADH dehydrogenase (ubiquinone) Fe-S protein 7	0,638	0.00280
NDUFA10	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 10	0,654	0.00101
IDH3G	Isocitrate dehydrogenase 3 (NAD), gamma	0,655	0.00041
ATAD3A	ATPase family, AAA domain containing 3A	0,658	0.00060
RGD735029	SEL1 domain containing protein	0,659	0.00097
RGD1303003	Homolog of zebrafish ES1	0,661	0.00011
RGD1303272	Similar to RIKEN cDNA 2010311D03	0,662	0.00218
HADHB	Hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), beta subunit	0,662	0.00078
CS	Citrate synthase	0,663	0.00559
GRPEL1	GrpE-like 1, mitochondrial	0,666	0.00101
PDP2	Pyruvate dehydrogenase phosphatase isoenzyme 2	0,668	0.00489
HSD17B10	Hydroxysteroid (17-beta) dehydrogenase 10	0,670	0.00185

FC: fold change versus sham controls.