Review Article

In Vivo Confocal Microscopy of the Human Cornea in the Assessment of Peripheral Neuropathy and Systemic Diseases

Table 3

Corneal subbasal nerve densities on in vivo confocal microscopy in diabetes mellitus.

Corneal subbasal nerve density in patients (mm/mm2)Corneal subbasal nerve density in controls (mm/mm2)

Petropoulos et al. [14], type 1 diabetes
 No retinopathy20.6 ± 1.527.7 ± 1.1
 Retinopathy17.4 ± 0.927.7 ± 1.1
 No microalbuminuria19.9 ± 1.727.7 ± 1.1
 Microalbuminuria14.3 ± 1.427.7 ± 1.1
Misra et al. [19], type 1 diabetes11.0 ± 3.821.17 ± 4.2
Malik et al. [24], type 2 diabetes
 Mild10.8 ± 0.913.5 ± 0.3
 Moderate7.5 ± 1.113.5 ± 0.3
 Severe4.3 ± 1.513.5 ± 0.3
Tavakoli et al. [23], type 2 diabetes
 Mild 5.48 ± 0.4511.21 ± 0.88
 Moderate 3.01 ± 0.3911.21 ± 0.88
 Severe2.99 ± 0.3411.21 ± 0.88