Evolution of Action Potential Alternans in Rabbit Heart during Acute Regional Ischemia

Figure 3

Monitoring the susceptibility to alternans. (a) (Control) OAPs response to abrupt change of CL from 300 ms to 200 ms and subsequent return to 300 ms. Arrows on the top indicate the moments of the CL switch. Small amplitude transient alternans after the switch completely disappears by the 9th second from the beginning of the recording. (b) Recording from the same location at 7 minutes of ischemia. The same pacing protocol initiates significant sustained OAPA alternans at CL = 200 ms.

(a)

(b)