Efficacy of Olanzapine Combined Therapy for Patients Receiving Highly Emetogenic Chemotherapy Resistant to Standard Antiemetic Therapy

Table 4

Changes of complete response rate, complete control rate, and total control rate after receiving olanzapine combined with standard antiemetic therapy.

	Acute phase (0–24 h)			Delayed phase (24–120 h)			Overall phase (0–120 h)
	Without OLN	With OLN	value^*	Without OLN	With OLN	value^*	Without OLN	With OLN	value^*
No vomiting	44 (88%)	50 (100%)	0.03	35 (70%)	48 (96%)	<0.001	31 (62%)	48 (96%)	<0.001
No rescue therapy	27 (54%)	49 (98%)	<0.001	1 (2%)	41 (82%)	<0.001	1 (2%)	41 (82%)	<0.001
CR	26 (52%)	49 (98%)	<0.001	1 (2%)	41 (82%)	<0.001	1 (2%)	41 (82%)	<0.001
CC	24 (48%)	49 (98%)	<0.001	0 (0%)	41 (82%)	<0.001	0 (0%)	41 (82%)	<0.001
TC	17 (34%)	43 (86%)	<0.001	0 (0%)	21 (42%)	<0.001	0 (0%)	20 (40%)	<0.001

^*McNemar test.
OLN: olanzapine.
CR: complete response (no vomiting, no rescue, and any nausea).
CC: complete control (no vomiting, no rescue, and nausea grade 0 or 1).
TC: total control (no vomiting, no rescue, and nausea grade 0).