Is Vitamin D Deficiency Related to Accumulation of Advanced Glycation End Products, Markers of Inflammation, and Oxidative Stress in Diabetic Subjects?

Table 3

Multiple regression, effect of ageing, and duration of diabetes and DM type on selected independent variables.

	25(OH)D	eGFR	AGE-Fl	CML	SAF	sVAP-1	sRAGE	hsCRP	Grips
Corr. M.	0.75	0.001	0.001	0.049	0.001	0.002	0.004	0.016	0.001
Intercept	0.001	0.001	0.001	0.001	0.001	0.001	0.001	0.44	0.001
DM dur.	0.92	0.001	0.001	0.42	0.003	0.027	0.008	0.89	0.001
Age	0.28	0.001	0.001	0.09	0.001	0.09	0.29	0.28	0.08
DM type	0.52	0.84	0.24	0.60	0.71	0.28	0.38	0.07	0.47
	−0.01	0.27	0.20	0.03	0.24	0.06	0.05	0.03	0.17

25(OH)D: 25(OH)D₃; eGFR: estimated glomerular filtration rate; AGE-Fl: advanced glycation end products associated fluorescence of plasma; CML: N^ε-carboxymethyllysine; SAF: skin autofluorescence; sVAP-1: soluble vascular receptor adhesion protein-1; sRAGE: soluble receptor for advanced glycation end products; hsCRP: high sensitive C-reactive protein; corr. M.: corrected model; DM type: type 1 or type 2 diabetes; italics: due to not normal distribution statistics performed on logarithmically transformed data. In case of CML, sRAGE and hsCRP model was significant although age and type of diabetes explained ≤5% in their variability ().