The G Allele of CaSR R990G Polymorphism Increases Susceptibility to Urolithiasis and Hypercalciuria: Evidences from a Comprehensive Meta-Analysis

Table 1

Characteristics of studies included in the meta-analysis for associations between CaSR polymorphisms and urolithiasis risk.

CaSR A986S polymorphism							Case ()			Control ()			HWE
Year	Author	Ethnicity	Country	Genotyping	SOC	Subjects	A/A	A/S	S/S	A/A	A/S	S/S
2013	Han et al. [15]	Asian	China	Sequencing	PB	PHPT and healthy	64	5	1	215	15	0	Y
2013	Han et al. [15]	Asian	China	Sequencing	HB	PHPT patients	64	5	1	88	6	0	Y
2011	Kim et al. [5]	Asian	Korea	PCR	PB	Healthy population	415	18	0	191	6	0	Y
2010	Shakhssalim et al. [13]	Asian	Iran	Sequencing	PB	Healthy population	71	26	2	93	14	0	Y
2009	Hamilton et al. [16]	Caucasian	Canada	Sequencing	PB	Healthy population	157	56	10	469	191	16	Y
2007	Scillitani et al. [17]	Caucasian	Canada	Sequencing	PB	PHPT and healthy	78	36	7	282	130	20	Y
2007	Scillitani et al. [17]	Caucasian	Canada	Sequencing	HB	PHPT patients	78	36	7	52	38	14	Y
2006	Corbetta et al. [18]	Caucasian	Italy	Taqman	HB	PHPT and healthy	30	12	1	91	42	4	Y
2006	Corbetta et al. [18]	Caucasian	Italy	Taqman	HB	PHPT patients	30	12	1	24	14	6	Y
2002	Vezzoli et al. [14]	Caucasian	Italy	Sequencing	PB	Healthy population	157	74		57	44		/
CaSR R990G polymorphism							Case ()			Control ()			HWE
Year	Author	Ethnicity	Country	Genotyping	SOC	Subjects	R/R	R/G	G/G	R/R	R/G	G/G
2013	Han et al. [15]	Asian	China	Sequencing	PB	PHPT and healthy	20	40	10	50	119	61	Y
2013	Han et al. [15]	Asian	China	Sequencing	HB	PHPT patients	20	40	10	24	53	17	Y
2010	Shakhssalim et al. [13]	Asian	Iran	Sequencing	PB	Healthy population	87	10	2	105	2	0	Y
2009	Hamilton et al. [16]	Caucasian	Canada	Sequencing	PB	Healthy population	171	38	14	568	102	6	Y
2007	Scillitani et al. [17]	Caucasian	Canada	Sequencing	PB	PHPT and healthy	105	16	0	391	41	0	Y
2007	Scillitani et al. [17]	Caucasian	Canada	Sequencing	HB	PHPT patients	105	16	0	102	2	0	Y
2006	Corbetta et al. [18]	Caucasian	Italy	Taqman	HB	PHPT and healthy	34	9		128	9		/
2006	Corbetta et al. [18]	Caucasian	Italy	Taqman	HB	PHPT patients	34	9		43	1		/
2002	Vezzoli et al. [14]	Caucasian	Italy	Sequencing	PB	Healthy population	216	15		100	1		/
CaSR Q1011E polymorphism							Case ()			Control ()			HWE
Year	Author	Ethnicity	Country	Genotyping	SOC	Subjects	Q/Q	Q/E	E/E	Q/Q	Q/E	E/E
2010	Shakhssalim et al. [13]	Asian	Iran	Sequencing	PB	Healthy population	94	5	0	107	0	0	Y
2007	Scillitani et al. [17]	Caucasian	Canada	Sequencing	PB	PHPT and healthy	113	8	0	402	30	0	Y
2007	Scillitani et al. [17]	Caucasian	Canada	Sequencing	HB	PHPT patients	113	8	0	102	2	0	Y
2002	Vezzoli et al. [14]	Caucasian	Italy	Sequencing	PB	Healthy population	222	9	0	98	3	0	Y

PB: Population-based study, HB: hospital-based study, and HWE: Hardy-Weinberg equilibrium.