The G Allele of CaSR R990G Polymorphism Increases Susceptibility to Urolithiasis and Hypercalciuria: Evidences from a Comprehensive Meta-Analysis

Table 2

Characteristics of individual studies included in the meta-analysis of CaSR polymorphisms and urine calcium concentration.

CaSR A986S polymorphism
Author	Year	Ethnicity	Country	Sample size	Subjects	AA	Mean	SD	AS + SS	Mean	SD
Han et al. [15]	2013	Asian	China	164	PHPT patients	151	413.47	204.96	13	506.05	180.5
Kim et al. [5]	2011	Asian	Korea	433	urolithiasis patients	415	190.3	112	18	138.6	84
Ferreira et al. [19]	2010	Mixed	Brazil	187	urolithiasis patients	177	239	100	10	280	86
Vezzoli et al. [20]	2007	Caucasian	Italy	243	Females	168	6.01	0.233	75	5.72	0.323
Pérez-Castrillón et al. [21]	2006	Caucasian	Spain	48	osteoporotic women	33	219	124	15	175	175
Corbetta et al. [18]	2006	Caucasian	Italy	79	PHPT patients	51	6.76	3.93	28	7.61	4.27
Harding et al. [22]	2006	Caucasian	England	188	dizygotic female twin pairs	141	0.44	0.15	47	0.46	0.18
Kelly et al. [23]	2006	Caucasian	England	121	Healthy populations	90	0.2	0.09	31	0.19	0.1
Vezzoli et al. [14]	2002	Caucasian	Italy	207	urolithiasis patients	133	6.91	0.26	74	7.96	0.46
CaSR R990G polymorphism
Author	Year	Ethnicity	Country	Sample size	Subjects	RR	Mean	SD	RG + GG	Mean	SD
Corbetta et al. [18]	2006	Caucasian	Italy	79	PHPT patients	69	6.77	4.31	10	9.05	2.05
Harding et al. [22]	2006	Caucasian	England	188	Dizygotic female twin pairs	167	0.45	0.17	21	0.4	0.42
Vezzoli et al. [14]	2002	Caucasian	Italy	148	Urolithiasis patients	133	6.91	0.26	15	9.68	0.87
Shakhssalim et al. [13]	2010	Asian	Iran	206	Urolithiasis and healthy	192	187.06	99.75	14	214.43	99.23
Ferreira et al. [19]	2010	Mixed	Brazil	185	Urolithiasis patients	177	239	100	8	283	112
Vezzoli et al. [20]	2007	Caucasian	Italy	243	Females	220	5.82	0.196	23	7.59	0.63
CaSR Q1011E polymorphism
Author	Year	Ethnicity	Country	Sample size	Subjects	QQ	Mean	SD	QE + EE	Mean	SD
Vezzoli et al. [20]	2007	Caucasian	Italy	243	Females	230	6.03	0.193	13	5.2	0.966
Harding et al. [22]	2006	Caucasian	England	188	Dizygotic female twin pairs	172	0.45	0.14	16	0.37	0.62
Vezzoli et al. [14]	2002	Caucasian	Italy	142	Urolithiasis patients	133	6.91	0.26	9	6	0.91
Shakhssalim et al. [13]	2010	Asian	Iran	206	Urolithiasis and healthy	201	233.6	139.9	5	187.81	98.73
Ferreira et al. [19]	2010	Mixed	Brazil	185	Urolithiasis patients	177	239	100	4	287	80