Characteristic Gene Expression Profiles of Human Fibroblasts and Breast Cancer Cells in a Newly Developed Bilateral Coculture System

Figure 2

Electron microscopic views of cells in coculture. (a) Fibroblasts were cocultured with HCC1937 breast cancer cells (lower photo). As a control, fibroblasts were cultured with fibroblasts (upper photo). In coculture with HCC1937 cells, morphological change of cellular body shape and vacuole-like spaces were observed. (b) HCC1937 breast cancer cells were cocultured with fibroblasts (lower photo). As a control, HCC1937 cells were cultured with HCC1937 cells (upper photo). By coculture with fibroblasts, morphological changes of round shape were observed. Optical microscopic photos were shown at the top right corner.

(a) Fibroblast

(b) HCC1937 breast cancer cell