Characteristic Gene Expression Profiles of Human Fibroblasts and Breast Cancer Cells in a Newly Developed Bilateral Coculture System

Table 4

Enrichment analysis: downregulation in fibroblasts.

#	Downregulation: GO processes with MCF7	value	FDR
1	Mitotic cell cycle
2	Cell cycle
3	Mitotic cell cycle process
#	Downregulation: GO processes with SKBR3	value	FDR
1	Regulation of lipid metabolic process
2	Positive regulation of biological process
3	Regulation of protein metabolic process
#	Downregulation: GO processes with HCC1937	value	FDR
1	Translation
2	Cellular macromolecular complex assembly
3	Nuclear-transcribed mRNA catabolic process
#	Downregulation: metabolic networks with MCF7	value	FDR
1	2-Oleoyl-glycerol_3-phosphate pathway
2	Lysophosphatidic acid pathway
3	1-Hexadecanoyl-glycerol_3-phosphate pathway
#	Downregulation: metabolic networks with SKBR3	value	FDR
1	N-Acyl-sphingosine phosphate pathway
2	1,2-Didocosapentaenoyl-sn-glycerol_3-phosphate pathway
3	1,2-Dioleoyl-sn-glycerol_3-phosphate pathway
#	Downregulation: metabolic networks with HCC1937	value	FDR
1	Amino acid metabolism_lysine metabolism and transport
2	Carbohydrate metabolism_pyruvate metabolism and transport
3	Glucosylceramide pathways and transport