| | # | Upregulation: GO processes in common versus MCF7, SKBR3, and HCC1937 (130 genes) | value | FDR |
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1 | Single-organism cellular process | | | | SMURF, FTS, ATF-4, AP-3 sigma subunits, SAT-1, Tenascin-C, GLSL, COUP-TFII, GCR-beta, SLIT2, SLFN5, TRUNDD(TNFRSF10D), MCT1 (SLC16A1), Neuropilin-1, RRN3, GLSK, SMAD6, FoxD1, and NIP3 |
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2 | Response to organic cyclic compound | | | | Tenascin-C, COUP-TFII, GCR-beta, SLIT2, MCT1 (SLC16A1), SMAD6, TIMP3, MKP-3, MKP-1, Lysyl oxidase, Adipophilin, COUP-TFI, Stromelysin-1, SLIT3, Stanniocalcin 2, and VEGF-A |
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3 | Single-organism process | | | | SMURF, FTS, MOXD1, ATF-4, AP-3 sigma subunits, SAT-1, Tenascin-C, GLSL, COUP-TFII, GCR-beta, SLIT2, SLFN5, TRUNDD(TNFRSF10D), MCT1 (SLC16A1), Neuropilin-1, RRN3, GLSK, SMAD6, and TIMP3 |
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4 | Response to endogenous stimulus | | | | SMURF, AP-3 sigma subunits, Tenascin-C, COUP-TFII, GCR-beta, SLIT2, SMAD6, TIMP3, PINCH, Connexin 43, SMURF2, GCR-alpha, PDGF-C, MKP-1, Lysyl oxidase, Stromelysin-1, SLIT3, and VEGF-A |
| |
5 | Organic anion transport | | | | SAT-1, GLSL, MCT1 (SLC16A1), GLSK, MCT4, CAT-1 (SLC7A1), Connexin 43, GLUT3, Adipophilin, SLC25A4, SLC38A1, Carbonic anhydrase XII, SLC38A2, SLC27A3, CAT-3, SLC7A5, and ANT |
| | # | Upregulation: metabolic networks in common versus MCF7, SKBR3, and HCC1937 (130 genes) | value | FDR |
| | 1 | Carbohydrate metabolism_glycolysis, glycogenesis, and glucose transport | | | | PFKP, GLUT3, ALDOC, ENO2, ALDOA, and ENO |
| | 2 | Carbohydrate metabolism_sucrose metabolism and transport | | | | COUP-TFII, GLUT3, COUP-TFI, Glycogen phosphorylase, and PYGL |
| | 3 | (L)-Proline pathways and transport | | | | CAT-1 (SLC7A1), Glycogen phosphorylase, SLC38A2, CAT-3, SLC7A5 |
| | 4 | L-Serine pathways and transport | | | | CAT-1 (SLC7A1), SLC38A1, SLC38A2, CAT-3, and SLC7A5 |
| | 5 | (S)-Citrulline pathway | | | | CAT-1 (SLC7A1), Glycogen phosphorylase, CAT-3, and SLC7A5 |
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| | # | Downregulation: GO processes in common versus MCF7, SKBR3, and HCC1937 (107 genes) | value | FDR |
| |
1 | Response to organic substance | | | | ERG1, IDI1, HSBP3, Ribonucleotide reductase, Galpha(s)-specific prostanoid GPCRs, MGMT, Cathepsin S, GREM2, MMP-13, SFRS3, BMP2, H-FABP, ACAT2, MGST3, IBP2, NNMT, CCL2, and DNAJA3 |
| | 2 | Regulation of immune complex clearance by monocytes and macrophages | | | | CCL2, CCL13, Galpha(q)-specific peptide GPCRs, Galpha(i)-specific peptide GPCRs |
| | 3 | Positive regulation of immune complex clearance by monocytes and macrophages | | | | CCL2, CCL13, Galpha(q)-specific peptide GPCRs, and Galpha(i)-specific peptide GPCRs |
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4 | Response to endogenous stimulus | | | | Ribonucleotide reductase, Galpha(s)-specific prostanoid GPCRs, MGMT, Cathepsin S, MMP-13, SFRS3, BMP2, H-FABP, MGST3, IBP2, NNMT, CCL2, CCL13, and Galpha(q)-specific peptide GPCRs |
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5 | Response to acid | | | | Galpha(s)-specific prostanoid GPCRs, MGMT, BMP2, H-FABP, ACAT2, IBP2, CCL2, CCL13, Galpha(q)-specific peptide GPCRs, Galpha(i)-specific peptide GPCRs, PGD2R, PEDF (serpinF1), INSIG1, and CD9 |
| | # | Downregulation: metabolic networks in common versus MCF7, SKBR3, and HCC1937 (107 genes) | value | FDR |
| | 1 | Steroid metabolism_cholesterol biosynthesis | | | | ERG1, IDI1, ACAT2, DHC24, MVD, and DHCR7 |
| | 2 | GalNAcbeta1-3Gal pathway | | | | Coagulation factor X, Galpha(q)-specific peptide GPCRs, Galpha(i)-specific peptide GPCRs, and CD13 |
| | 3 | N-Acyl-sphingosine phosphate pathway | | | | Galpha(q)-specific peptide GPCRs, PLAU (UPA), and MMP-1 |
| | 4 | Lipid metabolism_n-6 polyunsaturated fatty acid biosynthesis | | | | FADS2, FADS1 |
| | 5 | Glucosylceramide pathways and transport | | | | FADS2, FADS1 |
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