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BioMed Research International
Volume 2015 (2015), Article ID 964842, 8 pages
Review Article

Wnt/β-Catenin Signaling Pathway in Skin Carcinogenesis and Therapy

1Institute of Tropical Medicine, Third Military Medical University, 30 Gaotanyan Street, Chongqing 400038, China
2Department of Hematology, Southwest Hospital, Third Military Medical University, 30 Gaotanyan Street, Chongqing 400038, China
3Center for Engineering in Medicine, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, 51 Blossom Street, Boston, MA 02114, USA

Received 9 January 2015; Revised 6 April 2015; Accepted 21 April 2015

Academic Editor: Pascale Quatresooz

Copyright © 2015 Jing Li et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Cooperating with other signaling pathways, Wnt signaling controls cell proliferation, morphology, motility, and embryonic development destination and maintains the homeostasis of tissues including skin, blood, intestine, and brain by regulating somatic stem cells and their niches throughout adult life. Abnormal regulation of Wnt pathways leads to neoplastic proliferation in these tissues. Recent research shows that Wnt signaling is also associated with the regulation of cancer stem cells (CSCs) through a similar mechanism to that observed in normal adult stem cells. Thus, the Wnt/β-catenin signaling pathway has been intensively studied and characterized. For this review, we will focus on the regulation of the Wnt/β-catenin signaling pathway in skin cancer. With the important role in stemness and skin CSC proliferation, the Wnt/β-catenin signaling pathway and its elements have the potential to be targets for skin cancer therapy.