|
| Source | Number of patients | Age, Y | Gender
(male : female) | Blood samples |
|
2010
Li et al. [27] | DS: 30 HCC cases and 30 controls
TS: 30 HCC cases and 30 controls
VS: 55 HCC cases and 50 controls | 37.52 ± 12.09
(range: 20–67) | 74 : 86 | All the blood samples were collected before any operation, chemotherapy, and/or radiation treatment |
|
2011
Li et al. [25] | 46 HCC cases and 20 HCs | <50, 18;
⩾50, 28 | 33 : 13 | Serum samples of HCC were obtained from patients prior to definitive therapy |
|
2011
Gui et al. [26] | DS: 3 HCC cases and 2 HCs
VS: 46 HCC cases,
23 CHB cases, and 24 HCs | HCC: 54 ± 9
CHB: 41 ± 9
HCs: 51 ± 6 | HCC: 39 : 7
CHB: 17 : 6
HCs: 17 : 7 | None of the enrolled HCC, ICC, and FNH patients had received any adjuvant therapy or other treatments before blood sampling |
|
2011
Xu et al. [23] | 101 HCC cases,
48 CHB cases, and 89 HCs | HCC: ⩽50, 39;
>50, 62
CHB: ⩽50, 38
>50, 10
HCs: ⩽50, 36
>50, 53. | HCC: 78 : 23
CHB: 31 : 17
HCs: 68 : 21 | Preoperative and postoperative plasma samples were collected
Postoperative plasma samples were obtained 10–30 days after surgery under the confirmation of no obvious recurrence by ultrasonography, CT, and/or MRI |
|
2011
Qi et al. [24] | DS: 10 HCC cases and 10 HCs
VS: 48 HCC cases,
48 CHB cases, and 24 HCs | HCC: 49
CHB: 45
HCs: 38 | HCC: 55 : 15
CHB: 37 : 11
HCs: 24 : 10 | Blood samples were taken at the time of initial consultation before definitive surgical intervention and/or adjuvant therapy |
|
2012
Liu et al. [20] | 57 HCC cases,
29 CHB cases, and 30 HCs | HCC: ⩾60, 47;
<60, 10
CHB: ⩾60, 28;
<60, 1
HCs: ⩾60, 0
<60, 30 | HCC: 49 : 8
CHB: 20 : 9
HCs: 22 : 8 | Blood samples were collected before and 1 month after surgical resection |
|
2012
Li et al. [21] | DS: 15 HCC cases and 15 HCs
VS: 86 HCC cases,
30 CHB cases, and 45 HCs | HCC: 54 ± 11
CHB: 51 ± 13
HCs: 52 ± 16 | HCC: 76 : 25
CHB: 23 : 7
HCs: 46 : 14 | The preoperative serum samples were collected from 1 to 4 days before surgery, whereas the postoperative serum samples were collected from 8 to 359 days after surgery |
|
2011
Zhou et al. [22] | DS: 57 HCC cases, 25 LC cases,
22 CHB cases, and 33 HCs
TS: 204 HCC cases, 60 LC cases,
75 CHB cases, and 68 HCs
VS: 196 HCC cases, 56 LC cases,
72 CHB cases, and 66 HCs | TS: HCC 53 ± 12
LC: 53 ± 13
CHB: 39 ± 13
HCs: 44 ± 11
VT: HCC 53 ± 12
LC: 50 ± 10
CHB: 39 ± 14
HCs: 45 ± 12 | TS: HCC: 168 : 36
LC: 43 : 17
CHB: 48 : 27
HCs: 35 : 33
VS: HCC 166 : 30
LC: 40 : 16
CHB: 35 : 37
HCs: 43 : 23 | No patients received surgery or chemotherapy or radiotherapy before blood sampling |
|
2013
Lu et al. [19] | 41 HCC cases,
8 LC cases, and 10 HCs | HCC: 57 ± 11.5
LC: 54.5 ± 6.6
HCs: 54.3 ± 14.5 | HCC: 33 : 8
LC 5 : 3
HCs 5 : 5 | No details |
|
2013
Wei et al. [18] | No details | No details | No details | Blood samples were obtained from patients undergoing surgical HCC resection |
|
2013
Zheng et al. [17] | 96 HCC cases | <60, 40;
⩾60, 52 | HCC: 68 : 28 | None of the enrolled HCC patients had received any adjuvant therapy or other treatments before blood sampling. The postoperative blood samples were collected one week after surgery and the relapsed blood samples were collected at the department of surgery |
|
