Comparison of Monkeypox Virus Clade Kinetics and Pathology within the Prairie Dog Animal Model Using a Serial Sacrifice Study Design

Figure 1

Antibody response in MPXV challenged prairie dogs. Groups of prairie dogs were serially sacrificed (days 2, 4, 6, 9, 12, 17, and 24) following intranasal challenge (8 × 10³ pfu) with Congo Basin (CB) or West African (WA) MPXV. Antibody response at time of sacrifice by ELISA is shown for individual MPXV infected prairie dogs (CB (a) and WA (b)). Kinetics of antibody titers for two animals that were serially bled throughout the study are shown in (c). Neutralizing titers for animals sacrificed on or before day 9 as determined by HCS-GFP are shown in (d); two animals sacrificed on day 17 p.i. serve as positive controls.

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