An Expedient Synthesis, Acetylcholinesterase Inhibitory Activity, and Molecular Modeling Study of Highly Functionalized Hexahydro-1,6-naphthyridines

Table 1

Physical data and AChE inhibitory activity of naphthyridines (4a–k).

Entry	Product	Reaction time (min)	Yield; (%)	mp °C	AChE inhibition; (IC50  ± SD) mol/L
1		8	75	211-212	11.18 ± 0.02
2		7	72	229-230	7.20 ± 0.02
3		7	76	220-221	15.21 ± 0.1
4		6	70	208-209	18.16 ± 0.02
5		9	67	215-216	2.12 ± 0.02
6		6	72	225-226	24.72 ± 0.01
7		6	70	206-207	16.86 ± 0.02
8		7	73	235-236	7.16 ± 0.02
9		6	78	221-222	3.86 ± 0.02
10		7	74	218-219	14.16 ± 0.02
11		10	65	204-205	6.86 ± 0.02
12	Galantamine.HBr	—	—	—	2.09 ± 0.02