Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2015, Article ID 968672, 4 pages
http://dx.doi.org/10.1155/2015/968672
Research Article

Structural and Function Correlation of Cone Packing Utilizing Adaptive Optics and Microperimetry

1Department of Retina, Narayana Nethralaya, No. 121/C, 1st R Block, Rajajinagar, Bangalore 560010, India
2Department of Cataract & Refractive Surgery, Narayana Nethralaya, No. 121/C, 1st R Block, Rajajinagar, Bangalore 560010, India
3Department of Cornea & Refractive Surgery, Narayana Nethralaya, No. 121/C, 1st R Block, Rajajinagar, Bangalore 560010, India
4Department of Ophthalmology, Maastricht University, P.O. Box 616, 6200 MD Maastricht, Netherlands
5Forus Health Pvt. Ltd, No. 2234, 23rd Cross Road, Banashankari Stage II, Banashankari, Bangalore, India

Received 12 September 2014; Accepted 16 January 2015

Academic Editor: Michele Figus

Copyright © 2015 Dabir Supriya et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Aim. To assess the functional aspects of cone mosaic and correlate cone packing with retinal sensitivity utilizing microperimetry in emmetropes at different eccentricities. Methods. Twenty-four healthy volunteers underwent microperimetry (MAIA Centervue, Italy) and assessment of photoreceptors using adaptive optics retinal camera, rtx1 (Imagine Eyes, Orsay, France), at 2 and 3 degrees from the foveal centre in 4 quadrants: superior, inferior, temporal, and nasal. Data was analyzed using SPSS version 17 (IBM). Spearman’s correlation tests were used to establish correlation between mean cone packing density and retinal sensitivity at different quadrants. Results. Thirteen females and 11 males (age range 20–40 years) were included. The cone density was found to be significantly different among all quadrants (temporal = 25786.68/mm2 ± 4367.07/mm2, superior = 23009.35/mm2 ± 5415.81/mm2, nasal = 22838.09/mm2 ± 4166.22/mm2, and inferior = 21097.53/mm2 ± 4235.84/mm2). A statistical significance was found between orthogonal meridians, that is, temporal, nasal superior, inferior (44106.88/mm2). A drop in retinal sensitivity was observed as the eccentricity increased . It was also found that as cone packing density decreased retinal sensitivity also decreased in all quadrants. This was observed at both 2 and 3 degrees. Conclusion. It is of crucial importance to establish normative variations in cone structure-function correlation. This may help in detection of subtle pathology and its early intervention.