Epoetin Alpha and Epoetin Zeta: A Comparative Study on Stimulation of Angiogenesis and Wound Repair in an Experimental Model of Burn Injury

Figure 2

H&E stained sections of burned skin at day 12 observed under light microscopy. Skin of untreated animals (a) shows necrosis surrounded by a contraction of the panniculus carnosus as well as disorganized dermal-epidermal layers. Animals treated with EPO-α (b) demonstrate a well regenerated tissue with a keratin layer and reorganized subdermal structures. Animals treated with EPO-Z (c) show a still incomplete healing process characterized by a linear external layer with a low staining of hair keratin compared with the EPO-α treated group. The graph (d) represents the mean of epidermal regeneration and granulation tissue thickness at several time points in the studied animals. versus untreated; versus untreated; versus untreated; versus untreated; versus EPO-Z; versus EPO-Z; versus EPO-Z. Significance between treatments is considered within the same day of observation.

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