Curcumin and Its Analogue Induce Apoptosis in Leukemia Cells and Have Additive Effects with Bortezomib in Cellular and Xenograft Models

<div>Correlation of gene expression changes following curcumin and C-150 treatment (a). Correlation of gene expression values of the combined treatments of curcumin + bortezomib and C-150 (0.6 <i>μ</i>M) + bortezomib (b). The natural compound curcumin and its synthetic analogue C-150 affected nearly the same genes in a similar fashion, but curcumin analogue exerted its effect at 40-fold lower concentration.</div>

BioMed Research International

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Figure 4: Curcumin and Its Analogue Induce Apoptosis in Leukemia Cells and Have Additive Effects with Bortezomib in Cellular and Xenograft Models 