Curcumin and Its Analogue Induce Apoptosis in Leukemia Cells and Have Additive Effects with Bortezomib in Cellular and Xenograft Models

Figure 5

Survival of HL-60 xenograft mice treated with C-150 (3 mg/kg), bortezomib (0.15 mg/kg), or their combination. The curcumin analogue C-150 and bortezomib alone exhibited antitumor activity in HL-60 xenograft SCID mice, whereas combined treatment (bortezomib + C-150) developed a greater antitumor activity compared to single treatments.