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BioMed Research International
Volume 2015 (2015), Article ID 968981, 11 pages
Research Article

Curcumin and Its Analogue Induce Apoptosis in Leukemia Cells and Have Additive Effects with Bortezomib in Cellular and Xenograft Models

1AVIDIN Ltd., Alsókikötő Sor 11, Szeged, Hungary
2Department of Pharmaceutical Technology, University of Szeged, Eötvös u 6, Szeged 6720, Hungary
3Department of Hematology, Institute of Internal Medicine, University of Debrecen, Nagyerdei Körút 98, Debrecen 4032, Hungary
4Institute of Genetics, Biological Research Center of the Hungarian Academy of Sciences, Temesvári Körút 62, Szeged 6726, Hungary

Received 26 February 2015; Accepted 4 March 2015

Academic Editor: Walter Jaeger

Copyright © 2015 L. I. Nagy et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

"Supplementary Table: Normalized gene expression values (∆∆Ct) of all tested conditions. Curcumin and its analogue (C-150) induced expression changes in apoptotic and cell-cycle related genes as determined by high-throughput QPCR. Most of the affected genes showed similar changes suggesting that the related compounds act through similar signaling pathways. C-150 possessed dose dependent effects on certain apoptosis and cell cycle related genes in 40-fold lower concentration than curcumin which could be enhanced by coadministration with bortezomib. Red cells: at least 2 fold induction, green cells: at least 2 fold repression, nd: not detected transcript.

  1. Supplementary Table