Curcumin and Its Analogue Induce Apoptosis in Leukemia Cells and Have Additive Effects with Bortezomib in Cellular and Xenograft Models

Table 2

Cell viability measurements of curcumin (C), C-150, and bortezomib (BTZ) alone and in combination with CellTiter-Glo assay. Curcumin and its analogue C-150 significantly potentiated the effect of bortezomib (: bortezomib versus combination; : curcumin or C-150 versus combination; two-tailed Student’s -test).

	—	BTZ; (50 nM)	BTZ; (12.5 nM)	BTZ; (3.125 nM)	BTZ; (0.78 nM)
—		0.11	0.16	0.91	0.94
C (50 µM)	0.12	0.11	0.12	0.12	0.11
C (25 µM)	0.17	0.15	0.13	0.13; ()	0.13; ()
C (10 µM)	0.99	0.11	0.15	0.52; ()	0.87
C (5 µM)	1.08	0.11	0.17	0.79	1.05
C-150 (1 µM)	0.09	0.10	0.10; ()	0.08	0.08
C-150 (0.5 µM)	0.16	0.10	0.10	0.12	0.16
C-150 (0.1 µM)	0.99	0.08; ( )	0.12; ()	0.58; ( )	0.90
C-150 (0.05 µM)	0.93	0.10	0.15	0.69; ()	1.02