Roles of Akt and SGK1 in the Regulation of Renal Tubular Transport

Figure 1

Schematic structure of Akt1. Akt1 has 480 amino acids and it is composed of four domains: the pleckstrin homology domain, the helix domain, the kinase domain, and the regulatory domain. The kinase and the regulatory domains have phosphorylation sites at Thr308 and Ser473, respectively. Phosphorylation of these sites induces Akt1 activation.