Roles of Akt and SGK1 in the Regulation of Renal Tubular Transport

Figure 3

Effects of insulin on PT sodium transport. Insulin stimulates NBCe1 and NHE3 via IRS2/PI3K/Akt pathway. PPARγ and SGK1 may be involved in the stimulatory effect on PT sodium transport. NBCe1: sodium-bicarbonate cotransporter 1, NHE3: sodium-proton exchanger 3, PPARγ: peroxisome proliferator-activated receptor gamma, and SGK1: serum- and glucocorticoid-inducible kinase 1.