Acute and Chronic Toxicity, Cytochrome P450 Enzyme Inhibition, and hERG Channel Blockade Studies with a Polyherbal, Ayurvedic Formulation for Inflammation
Table 2
(a) Hematology in rats treated with BV-9238 (male) for chronic toxicity studies. (b) White blood cell differential count in %. (c) Hematology in rats treated with BV-9238 (female) for chronic toxicity studies. (d) White blood cell differential count in %.
(a)
Dose
Group I
Group II
Group III
Group IV
Vehicle control
1 g/kg/d
2 g/kg/d
2 g/kg/d
Hb (g%)
PCV (%)
RBC × 106/cm
WBC total × 103/cm
Clotting time (sec.)
(b)
Dose
Group I
Group II
Group III
Group IV
Vehicle control
1 g/kg/d
2 g/kg/d
2 g/kg/d
Neutrophils
Lymphocytes
Eosinophils
Monocytes
(c)
Dose
Group I
Group II
Group III
Group IV
Vehicle control
1 g/kg/d
2 g/kg/d
2 g/kg/d
Hb (g%)
PCV (%)
RBC × 106/cm
WBC total × 103/cm
Clotting time (sec.)
(d)
Dose
Group I
Group II
Group III
Group IV
Vehicle control
1 g/kg/d
2 g/kg/d
2 g/kg/d
Neutrophils
Lymphocytes
Eosinophils
Monocytes
Values are expressed as mean and standard deviation. Values are nonsignificant when compared with Group I (control) animals.
