Acute and Chronic Toxicity, Cytochrome P450 Enzyme Inhibition, and hERG Channel Blockade Studies with a Polyherbal, Ayurvedic Formulation for Inflammation

Table 3

(a) Serum chemistry in rats treated with BV-9238 (male) for chronic toxicity studies. (b) Serum chemistry in rats treated with BV-9238 (female) for chronic studies.

(a)

Dose	Group I	Group II	Group III	Group IV
	Vehicle control	1 g/kg/d	2 g/kg/d	2 g/kg/d
Total plasma protein (g%)
AST (IU/L)
ALT (IUL)
Blood urea (mg/dL)
Alk. phos. (IUL)
Blood glucose (mg/dL)
Cholesterol (mg/dL)
Triglycerides (mg/dL)

Values are expressed as mean and standard deviation. Values are nonsignificant when compared with Group I (control) animals.

(b)

Dose	Group I	Group II	Group III	Group IV
	Vehicle control	1 g/kg/d	2 g/kg/d	2 g/kg/d
Total plasma protein (g%)
AST (IUL)
ALT (IUL)
Blood urea (mg/dL)
Alk. phos. (IUL)
Blood glucose (mg/dL)
Cholesterol (mg/dL)
Triglycerides (mg/dL)

Values are expressed as mean and S.D. Values are nonsignificant when compared with Group I (control) animals.