Acute and Chronic Toxicity, Cytochrome P450 Enzyme Inhibition, and hERG Channel Blockade Studies with a Polyherbal, Ayurvedic Formulation for Inflammation

Table 5

Effect of BV-9238 at a dose of (0.5 g/mL) on radioligand binding assay to potassium channel hERG receptors isolated from HEK-293 cells. Astemizole was kept as positive control and IC50 (50% inhibitory concentration) is given in parenthesis.

	hERG receptor	% inhibition	Reference compound (IC50)
1	Potassium channel hERG	−7	Astemizole (2.6 M)