BioMed Research International / 2015 / Article / Tab 5

Research Article

Acute and Chronic Toxicity, Cytochrome P450 Enzyme Inhibition, and hERG Channel Blockade Studies with a Polyherbal, Ayurvedic Formulation for Inflammation

Table 5

Effect of BV-9238 at a dose of (0.5 g/mL) on radioligand binding assay to potassium channel hERG receptors isolated from HEK-293 cells. Astemizole was kept as positive control and IC50 (50% inhibitory concentration) is given in parenthesis.

hERG receptor% inhibitionReference compound (IC50)

1Potassium channel hERG−7Astemizole (2.6 M)

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