Activating Transcription Factor 4 Promotes Angiogenesis of Breast Cancer through Enhanced Macrophage Recruitment

Figure 3

ATF4 increases the microvascular density in breast cancer tissue. (a) Immunofluorescence staining of CD31 showed the increased microvascular density in ATF4-overexpressing 4T1-Luc breast cancers. (b) Immunofluorescence staining of CD31 showed the increased microvascular density in ATF4-overexpressing 4TO7 breast cancers. (c) ATF4 did not significantly influence the expression of proangiogenic factors.

(a)

(b)

(c)