Activating Transcription Factor 4 Promotes Angiogenesis of Breast Cancer through Enhanced Macrophage Recruitment

Figure 4

ATF4 facilitates the recruitment of macrophages both in vitro and in vivo. (a) Immunofluorescence staining of F4/80 showed more macrophages infiltrating into ATF4-overexpressing 4T1-Luc breast cancer tissue compared to MCS group. (b) Immunofluorescence staining of F4/80 showed more macrophages infiltrating into ATF4-overexpressing 4TO7 breast cancer tissue compared to MCS group. (c) More Raw264.7 cells were recruited by the conditioned medium of ATF4-overexpressing 4T1-Luc cells. Data were representative of three independent experiments. (d) More Raw264.7 cells were recruited by the conditioned medium of ATF4-overexpressing 4TO7 cells. Data were representative of three independent experiments.

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