Targeted Mutation of Nuclear Bone Morphogenetic Protein 2 Impairs Secondary Immune Response in a Mouse Model

Figure 9

Mutant spleens were structurally similar to wild type but had fewer hemosiderin-laden macrophages. Spleens were harvested from wild type (a, c) and mutant (b, d) mice on day 38 (3 days after secondary infection). They were fixed, embedded in paraffin, stained with H&E, and examined using brightfield microscopy. Images were captured through 5x (a and b) and 10x (c and d) objectives. Hemosiderin-laden macrophages appear as large, rust-colored cells (some are marked with arrows) in these representative sections.

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